ИСТИНА

Reconstruction of bone defects in fractures remains a challenge. The risk of infection has led to widespread restrictions on the use of animal-derived bone substitutes and an increased interest in the development of fully synthetic polymer composites. The present work is devoted to the production of fully synthetic biodegradable composites for regenerative surgery. Open-pored samples based on dialdehyde polysaccharides were obtained in the following way: a collagen conjugate with dialdehyde polysaccharides was prepared, then it was mixed with water and various additives, and foamed from a frozen block. The composite tablet predominantly has pores with a diameter of 0.8-1 microns, which is most suitable for successful bone tissue regeneration. The rate of biodegradation in vitro was determined by the rate of release of L-hydroxyproline, since collagen contains a large amount of this amino acid. The use of dialdehyde dextran as a biodegradation inhibitor allows three times to reduce the rate of enzymatic hydrolysis. Highly oxidized dialdehyde carboxymethyl cellulose reduces the rate by 10 times. The interaction products of dialdehyde polysaccharides with collagen in in vivo experiments on Wistar mice degrade during subcutaneous implantation much slower than the initial collagen, which is probably due to a change in the substrate specificity of the product. Thus, fully synthetic, biodegradable bone-substituting materials capable of releasing physiologically active substances at different times based on dialdehyde polysaccharides have been developed.