ИСТИНА

A large number of currently used drugs have their origins in fungi. Steroids occupy an important place among fungal constituents. The vast majority of them are metabolites of ergosterol 1, the main fungal sterol involved in the regulation of membrane fluidity. A characteristic structural feature of many ergosterol metabolites is the presence of a unique steroid skeleton, different from that of the parent sterol. A number of such metabolites have shown some biological activity with potential pharmacological utility. The purpose of this work was to study the radical rearrangement of hydroxyperoxides 2 as a source of compounds with an unusual tetracyclic steroid skeleton, such as 13(14→8)abeo and 13(14→8),14(8→7)diabeo steroids 3 and 4. Biological tests have shown that a number of synthesized compounds have notable antiproliferative activity against breast cancer, prostate cancer and epidermoid carcinoma.