ИСТИНА

Introduction: the incidence of infectious complications after orthopedic surgery is increasing every year. Microbial pathogens form three-dimensional biofilms, only possible to be eradicated by lesion sanation and antibiotic therapy, local and/or systemic. Existing depot systems based on polymethyl methacrylate (PMMA) have several disadvantages. Methods: a comparative analysis of the antimicrobial activity of 13x8 mm cylinder samples based on biodegradable polymer hydrogel and PMMA was carried out against MSSA, MRSA, MSSE, MRSE and A. baumannii, sensitive to the tested antibiotics with different physicochemical properties. The bactericidal activity of microbe-antibiotic pairs: MSSA-gentamicin, MSSE-cefazolin, MRSA and MRSE-vancomycin, A. baumannii-tobramycin - was studied in 3 parallel studies. The study procedure was based at the disk diffusion microbiological method. The duration of the study was 7 days. Data was processed using Me and 95% CI, Mann-Whitney and Wilcoxon tests. Results: the antimicrobial effect of the polymer hydrogel against the leading pathogens of orthopedic infections from the first day of incubation was significantly (p = 0.002) higher than the activity of PMMA. The PMMA bactericidal effect was short-term (up to 3 days) with a significant (p = 0.042) decrease in activity on the 2nd day of cultivation. The inhibition zone around the hydrogel throughout the study (as a result of controlled diffusion of antibiotics) was reduced by an average of 1-2 mm. Conclusion: Polymer biodegradable hydrogels impregnated with antibiotics have greater antimicrobial potential compared to PMMA.