ИСТИНА

Interstitial fluid plays an important role in functioning of the tissue as tt provides transport of nutrients and chemical mediators to the cells of the body. Interstitial fluid enters the tissue from the arteriolar end of the microcirculatory system, and the absorption of its greater part occurs at its venous end A smaller part, about 10-15 percent, returns to the bloodstream through the lymphatic system. Angiogenesis, the process of new capillary formation, accompanying tumor growth, disrupts the regulation of interstitial fluid transport and often leads to edema formation in the peritumoral region. Experimental studies have shown that anti-angiogenic anticancer therapy leads to the edema reduction, and in some cases not just to tumor growth rate decrease, but also to its shrinkage. We believe that it is the dynamics of the interstitial fluid that is responsible for this effect. However, from the mathematical point of view, the description of such a biological system represents a challenge, since it is necessary to take into account a largenumber of interrelated processes. In the present talk, approaches to such a description will be considered and mathematical model will be presented to explain the experimentally observed facts.