Antioxidant Activity of Natural Allylpolyalkoxybenzene Plant Essential Oil Constituentsстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 6 февраля 2020 г.
Аннотация:Free-radical-scavenging capacity antioxidant
and membrane-protective properties of natural and related
synthetic allylpolyalkoxybenzenes with different numbers of
alkoxy/methoxy groups in the aromatic ring were evaluated
using several in vitro models. These included the DPPH assay,
inhibition of lipid peroxidation products accumulation,
inhibition of H2O2-induced hemolysis, and oxidation of
oxyhemoglobin. A synthetic protocol for the synthesis of
natural nothoapiol (9) from a parsley seed metabolite, apiol
(7), was developed. A structure−activity relationship study
revealed that both the methylenedioxy fragment and methoxy
groups in the aromatic ring are favorable for antioxidant
activity. Hydroxyapiol (14), containing a hydroxy group in the
aromatic core, was identified as the most potent compound. The pentaalkoxy-substituted nothoapiol (9) showed antioxidant
activity in mouse brain homogenates, whereas in mouse erythrocytes it exhibited a marked pro-oxidant effect. Despite their low
free-radical-scavenging capacity, allylpolyalkoxybenzenes can contribute to the total antioxidant potencies of plant essential oils.