Bone Marrow Involvement in Melanoma. Potentials for Detection of Disseminated Tumor Cells and Characterization of Their Subsets by Flow Cytometryстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 марта 2022 г.
Аннотация:Disseminated tumor cells (DTCs) are studied as a prognostic factor in many
non-hematopoietic tumors. Melanoma is one of the most aggressive tumors. Forty percent of
melanoma patients develop distant metastases at five or more years after curative surgery, and
frequent manifestations of melanoma without an identified primary lesion may reflect the tendency
of melanoma cells to spread from indolent sites such as bone marrow (BM). The purpose of this
work was to evaluate the possibility of detecting melanoma DTCs in BM based on the expression of
a cytoplasmatic premelanocytic glycoprotein HMB-45 using flow cytometry, to estimate the influence
of DTCs’ persistence in BM on hematopoiesis, to identify the frequency of BM involvement in
patients with melanoma, and to analyze DTC subset composition in melanoma. DTCs are found
in 57.4% of skin melanoma cases and in as many as 28.6% of stage I cases, which confirms the
aggressive course even of localized disease. Significant dierences in the groups with the presence
of disseminated tumor cells (DTCs+) and the lack thereof (DTC) are noted for blast cells, the total
content of granulocyte cells, and oxyphilic normoblasts of erythroid raw cells.