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CYTOCHROME P450 3A4 ACTIVITY AND GENETIC VARIANTS AS PREDICTORS OF LIVER FAILURE IN PATIENTS WITH OBSTRUCTIVE JAUNDICEстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 19 июня 2024 г.
- Авторы: Lebedev S.S., Tavobilov M.M., Karpov A.A., Abramov K.A., Bochkov P.O., Shevchenko R.V., Denisenko N.P., Shabunin A.V., Sychev D.A.
- Журнал: Free Radical Biology and Medicine
- Том: 208
- Год издания: 2023
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 229
- Последняя страница: 235
- Аннотация: Liver failure in patients with obstructive jaundice is a significant contributor to mortality within this patient cohort. The exact mechanism and triggers of this occurrence are yet to be fully understood. With this in mind, our study aimed to assess the correlation between the urinary 6 β-OHC/C ratio and various biochemical parameters of liver function. Furthermore, we conducted genotyping of CYP3A4*22 (rs35599367), CYP3A5*3 (rs776746) polymorphic markers to investigate the potential effects of their variants on the probability of liver failure in obstructive jaundice. Our study included 75 patients diagnosed with severe obstructive jaundice. All test subjects underwent functional liver tests, and control blood tests were administered on the seventh day following biliary decompression. Patients were categorized into two groups: group 1 - patients without liver failure (n = 60) and group 2 - patients with liver failure (n = 15). Laboratory indexes such as 6 β –OHC concentration and 6 β- OHC/cortisol ratio can serve as significant predictors of liver failure in patients with moderate and severe degree obstructive jaundice after biliary decompression
- Добавил в систему: Лебедев Сергей Сергеевич