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5-hydroxymethylcytosine in DNA repair: a new player or a red herring?статья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 октября 2017 г.
- Авторы: Kantidze Omar L., Razin Sergey V.
- Журнал: Cell Cycle
- Том: 16
- Номер: 16
- Год издания: 2017
- Издательство: Landes Bioscience
- Местоположение издательства: United States
- Первая страница: 1499
- Последняя страница: 1501
- DOI: 10.1080/15384101.2017.1346761
- Аннотация: Active DNA demethylation performed by ten-eleven translocation (TET) enzymes produces 5-hydroxymethylcytosines, 5-formylcytosines, and 5-carboxylcytosines. Recent observations suggest that 5-hydroxymethylcytosine is a stable epigenetic mark rather than merely an intermediate of DNA demethylation. However, the clear functional role of this new epigenetic player is elusive. The contribution of 5-hydroxymethylation to DNA repair is being discussed currently. Recently Jiang and colleagues have demonstrated that DNA damage response-activated ATR kinase phosphorylates TET3 in mammalian cells and promotes DNA demethylation and 5-hydroxymethylcytosine accumulation. Moreover, TET3 catalytic activity is important for proper DNA repair and cell survival. Here we discuss recent studies on the potential role of 5-hydroxymethylation in DNA repair and genome integrity maintenance.
- Добавил в систему: Разин Сергей Владимирович