Single-cell Hi-C bridges microscopy and genome-wide sequencing approaches to study 3D chromatin organization

Ulianov, S.V.; Kikue, T.; Razin, S.V.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 октября 2017 г.

Авторы: Ulianov Sergey V., Kikue Tachibana-Konwalski, Razin Sergey V.
Журнал: BioEssays
Том: 39
Год издания: 2017
Издательство: John Wiley & Sons Inc.
Местоположение издательства: United States
Первая страница: 1
Последняя страница: 8
DOI: 10.1002/bies.201700104
Аннотация: Recent years have witnessed an explosion of the single-cell biochemical toolbox including chromosome conformation capture (3C)-based methods that provide novel insights into chromatin spatial organization in individual cells. The observations made with these techniques revealed that topologically associating domains emerge from cell population averages and do not exist as static structures in individual cells. Stochastic nature of the genome folding is likely to be biologically relevant and may reflect the ability of chromatin fibers to adopt a number of alternative configurations, some of which could be transiently stabilized and serve regulatory purposes. Single-cell Hi-C approaches provide an opportunity to analyze chromatin folding in rare cell types such as stem cells, tumor progenitors, oocytes, and totipotent cells, contributing to a deeper understanding of basicmechanismsin development and disease. Here,we review key findings of single-cell Hi-C and discuss possible biological reasons and consequences of the inferred dynamic chromatin spatial organization.
Добавил в систему: Ульянов Сергей Владимирович

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Single-cell Hi-C bridges microscopy and genome-wide sequencing approaches to study 3D chromatin organizationстатья

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