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The ‘click’ synthesis of new cytotoxic conjugate based on meso-arylporphyrin and Erlotinibстатья
- Авторы: Bortnevskaya Yuliya S., Malikova Viktoriya А., Karpechenko Natalia Yu, Bragina Natal’ya A., Zhdanova Kseniya A.
- Журнал: Mendeleev Communications
- Том: 34
- Номер: 5
- Год издания: 2024
- Издательство: Russian Academy of Sciences
- Местоположение издательства: Russian Federation
- Первая страница: 685
- Последняя страница: 687
- DOI: 10.1016/j.mencom.2024.09.019
- Аннотация: New phototherapeutic agents based on synthetic porphyrintype tetrapyrroles and small-molecule-targeted tyrosine kinase inhibitor Erlotinib have been synthesized based on the scheme involving ‘click’ reaction between bis(4-azidophenyl)-containing zinc porphyrinate derivative and N-(3 ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-quinazoline. The final compound and its precursors weretested as potential photosensitizers for targeted photodynamic therapy (PDT), the conjugate having shown photoinduced cytotoxicity IC50 for NKE cells 0.86±0.017 µm and for A431 cells 0.54±0.011 µm.
- Добавил в систему: Карпеченко Наталья Юрьевна