Аннотация:A series of N-isonicotinoyl-3(5)-ferrocenyl-5(3)-substituted 1H-pyrazoles was obtainedas the mixtures of the products by acylation of tautomeric forms of 3-ferrocenyl-5-substituted 1H-pyrazoles with isonicotinoyl chloride. The rate of hydrolysis of the synthesizedcompounds depended on the electronic eff ects of the substituents in the pyrazole ring andincreased in the following order Me < Ph ≈ COOEt << CF3. The hydrolysis rate of thesynthesized compounds in acidic medium is signifi cantly higher than under neutral conditions, which is associated with the possibility of the redistribution of electron density inthe aromatic pyrazole ring upon the pyrazole protonation. The revealed regularities canbe used for designing the redox and pH sensors, acylating agents, and antituberculosisagents active aga inst isoniazid-resistant mycobacterium strains.
