Tripeptide Phe-Trp-Leu-NH2 as a putative endogenous ligand of TSPO: molecular modeling, synthesis and pharmacological activity

Авторы: Deeva O.A., Pantileev A.S., Kravtsova O.Yu, Nikolaev S.V., Zefirov N.A., Povarnina P.Yu, Antipova T.A., Gudasheva T.A., Dorofeev V.L.
Журнал: Mendeleev Communications
Том: 34
Номер: 5
Год издания: 2024
Издательство: Russian Academy of Sciences
Местоположение издательства: Russian Federation
Первая страница: 682
Последняя страница: 684
DOI: 10.1016/j.mencom.2024.09.018
Аннотация: The putative endogenous tripeptide ligand of the translocator protein (TSPO) l-phenylalanyl-l-tryptophanyl-l-leucine amide was obtained using the drug-based peptide design strategy and molecular modeling. This tripeptide demonstrated anxiolytic activity in the elevated plus-maze test and antidepressant-like activity in the forced swimming test in BALB/c mice at the doses of 10 mg per kg (i.p.) and also showed neuroprotective activity in the concentration range of 0.1–10 mM in vitro under conditions of oxidative stress using HT-22 neuronal cell line.
Добавил в систему: Зефиров Николай Алексеевич

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