Preparative Scalable Method for the Synthesis of Cyclic and Acyclic Acetals of Chloropropiolaldehyde and Their Transformation into Acetals of Lithiumpropiolaldehydeстатья
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Аннотация:A simple two-step and easily scalable method for the synthesis of cyclic and acyclic acetals of chloropropiolaldehyde was developed. They readily reacted with n-butyllithium to give stable crystalline acetals of lithiumpropiolaldehyde, which, being strong nucleophiles, reacted with chlorotrimethylsilane, chlorotrimethylstannane, and methyl chloroformate to form bifunctional acetylenes in high yields.
