The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells

Авторы: Kandrashina Snezhanna, Sherstyukova Ekaterina, Shvedov Mikhail, Inozemtsev Vladimir, Timoshenko Roman, Erofeev Alexander, Dokukin Maxim, Sergunova Viktoria
Журнал: Cells
Том: 13
Номер: 21
Год издания: 2024
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 1813
Последняя страница: 1813
DOI: 10.3390/cells13211813
Аннотация: Red blood cells respond to fluctuations in blood plasma pH by changing the rate of biochemical and physical processes that affect the specific functions of individual cells. This study aimed to analyze the effect of pH changes on red blood cell morphology and structure. The findings revealed that an increase or decrease in pH above or below the physiological level of pH 7.4 results in the transformation of discocytes into echinocytes and causes significant alterations in the membrane, including its roughness, cytoskeleton structure, and the cell’s elastic modulus. Furthermore, the study shown a strong connection between critical acidosis and alkalosis with increased intracellular reactive oxygen species production.
Добавил в систему: Шерстюкова Екатерина Александровна

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