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Novel HILIC stationary phases with grafted polymer acids and eremomycinтезисы доклада
- Авторы: Chikurova N.Y., Belyaeva A.A., Borodina A.F., Chernobrovkina A.V., Shpigun O.A.
- Сборник: HPLC 2024
- Тезисы
- Год издания: 2024
- Место издания: Chinese chemical society Dalian
- Аннотация: New methods for the construction of functional layers of hydrophilic adsorbents: the use of click chemistry, modification with polymers, large molecules can lead to the screening of substrates, increasing their hydrophilicity and selectivity. Moreover, the use of multicomponent reactions, opens up the possibility of creating completely different structural fragments, including polymeric ones. It is proposed to use the flexible Ugi reaction for creating a monomer and polymer functional layers on the substrate surface by “one-pot” synthesis. To characterize and compare the synthesized adsorbents the Tanaka test and polar compounds were used.The formation of monomer layers by Ugi reaction led to the production of effective silica gel adsorbents characterized by high selectivity. Phases with new polymer layers, characterized by an increased degree of substrate screening and stability, were obtained. It was found that the use of a linear copolymer with a high molecular weight of the unit led to the preparation of highly efficient phases. The introduction of different polymeric acids made it possible to control ion exchange selectivity of the phases.The possibility of using adsorbents containing eremomycin for the separation of polar compounds in a hydrophilic mode was demonstrated. The introduction of eremomycin into the layer led to a threefold increase in the hydrophilicity of the surface of different types of substrates; such hydrophilization of the polystyrene-divinylbenzene-based substrate, in turn, led to the production of an adsorbent suitable for hydrophilic, reversed-phase and chiral chromatography.This work was supported by the Russian Science Foundation through the grant № 20-13-00140.
- Добавил в систему: Чикурова Наталья Юрьевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Тезисы_-_Чикурова.pdf | 231,4 КБ | 3 декабря 2024 [Natalia_Chikurova] | |
| 2. | Заключение о возможности открытого публикования | HPLC-2024_Экспертное_Китай.pdf | 686,1 КБ | 3 декабря 2024 [Natalia_Chikurova] |