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Designed magnetic nanoparticles for ferroptosis: Release of iron ions from metal-organic frameworks modified with iron oxidesстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Bondarenko Lyubov, Baimuratova Rose, Reindl Marco, Zach Verena, Dzeranov Artur, Pankratov Denis, Osmushko Ivan, Kydralieva Kamila, Dzhardimalieva Gulzhian, Kolb Dagmar, Prassl Ruth, Sterrer Martin, Schwaminger Sebastian P.
- Журнал: Materials Today Chemistry
- Том: 42
- Год издания: 2024
- Издательство: Elsevier Ltd
- Местоположение издательства: London
- Первая страница: 1
- Последняя страница: 12
- Номер статьи: 102332
- DOI: 10.1016/j.mtchem.2024.102332
- Аннотация: The unique chemical properties of the catalytic and biocompatible metal organic framework MIL88b allow for considering it as prooxidant agent. The authors hypothesize whether additional modification of the MIL88b with an additional iron source as Fe3O4 nanoparticles can increase both pro-oxidant activity and provide magnetic properties contributing to target delivery. The prooxidant activity of the Fe3O4-MOF was studied using electron paramagnetic resonance spectroscopy and methylene blue degradation reactions in the presence of hydrogen peroxide. To understand the reaction mechanism, the authors studied the released iron ions, as well as the surface composition using the X-ray photoelectron spectroscopy method. The addition of iron oxide leads to a more prolonged release of iron ions and the production of hydroxyl radicals within 24 h. The native MIL88b demonstrates the highest Fenton reaction rate due to "sacrificial" behavior (despite lower concentration of iron ions in the composition and on the surface compared to the modified sample) and the blocking of the active centers of MIL88b by Fe3O4 on the surface.
- Добавил в систему: Панкратов Денис Александрович
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