Storage stability study of metronidazole and hydroxymetronidazole in chicken eggs by liquid chromatography tandem mass spectrometry

Авторы: Vokuev Mikhail, Melekhin Artem, Frolova Anastasia, Bairov Anton, Rodin Igor, Tishchenko Victor
Журнал: Food Chemistry: X
Том: 25
Год издания: 2025
Издательство: Elsevier B.V.
Местоположение издательства: Netherlands
Первая страница: 1
Последняя страница: 8
Номер статьи: 102087
DOI: 10.1016/j.fochx.2024.102087
Аннотация: Metronidazole (MNZ) is one of the most commonly used antibiotics in the food industry. High levels in food can lead to the development of antimicrobial resistance in humans, so it is important to monitor its levels in food. In the context of legal proceedings, it is frequently necessary to re-examine samples after an extended period of time. It is therefore crucial to ensure that the analytes in question do not degrade during the storage period. In this study, HPLC-MS/MS approach was validated and used to analyze levels of MNZ and its hydroxy metabolite in chicken eggs during storage in the refrigerator (+4 °C) and in the freezer (−20 °C) for 3 months. An analyte solution was administered to hens to obtain eggs containing MNZ and hydroxymetronidazole (MNZ-OH). The dependence of the analyte content in eggs as a function of time after sampling was also investigated.
Добавил в систему: Вокуев Михаил Фёдорович

№	Имя	Описание	Имя файла	Размер	Добавлен
1.	Экспертное заключение		экспертное_заключение_csNcLHl.pdf	444,5 КБ	23 декабря 2024 [VokuevMF]
2.	Полный текст	текст	1-s2.0-S2590157524009751-main.pdf	3,3 МБ	14 декабря 2024 [VokuevMF]
3.	экспертное_заключение.pdf		экспертное_заключение.pdf	444,5 КБ	23 декабря 2024 [VokuevMF]

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ФИЦ ПХФ и МХ РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА