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A Study of the Physicochemical Properties and Structure of Moxifloxacin Complex with Methyl-β-Cyclodextrinстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 октября 2017 г.
- Авторы: Skudredina A.A., Le-Deigen I.M., Uporov I.V., Kudryashova and E.V
- Журнал: Colloid Journal
- Том: 79
- Номер: 5
- Год издания: 2017
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 668
- Последняя страница: 676
- DOI: 10.1134/S1061933X17050143
- Аннотация: The physicochemical properties and structure of moxifloxacin‒methyl-β-cyclodextrin complex have been studied by UV spectroscopy, FTIR spectroscopy, and computer simulation. The optimal conditions for the formation of the complex have been determined, and the dissociation constant of the complex in acidic media (Kdis = (5.0 ± 0.3) × 10–5 М) has been obtained. It has been found that complexation signifi- cantly slows down the release of the drug in acidic media. Experimental results are in good agreement with computer simulation data. The following mechanism of complexation has been proposed: the incorporation of the aromatic skeleton of moxifloxacin into the cavity of methyl-β-cyclodextrin is followed by additional stabilization of the complex via multiple hydrophobic interactions and hydrogen bonding.
- Добавил в систему: Ле-Дейген Ирина Михайловна
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